Biological Age vs. Chronological Age: Can You Reverse the Clock?

Steve Horvath's epigenetic clock — published in Genome Biology in 2013 — changed the conversation about aging measurement forever. For the first time, it was possible to estimate biological age from blood or saliva with an error margin under 3.6 years. The more important finding: these clocks are not fixed. Exercise, diet, sleep, stress reduction, and select interventions have all been shown to shift methylation age downward.